By Derek Leroith
Traditionally the sector of endocrine examine has constantly been on the leading edge of clinical endeavors. The investigators of those very important breakthroughs in learn were rewarded via various Nobel awards. within the box of diabetes on my own, Nobel prizes were presented to researchers who chanced on insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. no longer unusually, biomedical researchers have continually been attracted via the endocrine method and different comparable structures of intercellular verbal exchange. over the last 20 years, endocrine examine has constructed quickly and tailored sleek molecular and mobile biology thoughts for its particular use. those alterations have allowed researchers within the box to take care of their side. therefore, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine problems. Our knowing of the law of gene expression has been drastically improved by way of molecular suggestions. In an try to convey investigators modern with the hot advances during this exploding box we have now made up our minds to post a chain entitled Advances in Molecular and mobile Endocrinology. the world over well-known investigators have agreed to take part and their contributions are preferred. quantity 1 has excited about facets of the hypothalamic-pituitary axis together with GnRH and GH gene law, molecular elements of insulin, insulin-like progress elements and glucagon. additionally, reports at the lately cloned calcium receptor and steroid receptor interactions with DNA are awarded.
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1994b). , 1994). , 1994a). Thus, the neurotransmitters NMDA and NO regulate GnRH secretion. One of the major signal transduction pathways involving the excitatory amino acid glutamate utilizes NO as a second messenger (Figure 6). Glutamate released from nerve terminals binds to the NMDA receptor on the postsynaptic membrane and activates an influx of calcium, which in turn binds to calmodulin (Nakanishi, GnRH Gene Expression 19 1992). The binding of the calcium/calmodulin complex to the enzyme, NOS, increases its conversion of arginine to NO (Bredt and Snyder, 1990).
Cell. Endocrinol. 102, 85-92. Chapter 2 MOLECULAR ASPECTS OF HORMONE DEFICIENCY CAUSED BY PIT-1 GENE MUTATIONS LAURIE E. COHEN, SALLY RADOVICK, and FREDRIC E. W O N D I S F O R D 31 32 33 34 36 40 41 44 Introduction Pit-1 Protein Splice Variants Pituitary Development Gene Activation and Regulation Phosphorylation Mutations of the Pit-1 Gene Summary INTRODUCTION Pit-1, also known as growth hormone factor-1 (GHF-1), is a member of a family of transcription factors, POU, responsible for mammalian development.
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